New York, USA, Jan. 13, 2025 (GLOBE NEWSWIRE) — Market Overview
With a CAGR of 4.3% from 2025 to 2034, the global refractory gout market is expected to increase from USD 1,050.21 million in 2024 to USD 1,599.24 million in 2034.
Market Introduction
A type of arthritis called gout results in excruciating joint swelling, usually in the big toe or lower limb. It results from the body’s buildup of uric acid, which causes needle-shaped crystals to form in the joints. These crystals lead to arthritis and inflammation. A rare, severe, and chronic form of gout that is difficult to treat is called refractory gout. Chronic arthritis, redness tophi (lumps that develop on the hands, elbows, and other parts of the body), joint pain, swelling, and serum uric acid levels higher than 6 mg/dL are some of the symptoms that set it apart. Functional impairment and a lower quality of life are two consequences of refractory gout. Kidney issues may also result from it.
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Growth Drivers
- Therapies, such as IL-1 inhibitors and monoclonal antibodies, have emerged as viable treatment choices for gout patients who do not react to conventional urate-lowering medications. These medications target particular inflammatory pathways linked to gout, providing focused treatment.
- The introduction of combination therapy helps to address the complexities of resistant gout. Combination therapies seek to manage both inflammation and uric acid levels, providing a multimodal approach for patients who have not responded to monotherapies.
Market Trends
- Advancements in genetic testing and biomarker identification are driving the shift to individualized medication in the refractory gout market.
- Future trends in the refractory gout market include an increased need for targeted treatments and the development of combination medications to address the unmet needs of patients with refractory gout.
Key Players in Refractory Gout Market
- LG Chem
- Pfizer Inc.
- AstraZeneca
- Mylan N.V.
- Sanofi
- GlaxoSmithKline plc (GSK)
- Ardea Biosciences
- Horizon Therapeutics
- Novartis AG
- Takeda Pharmaceuticals
- Grifols, S.A.
- Ironwood Pharmaceuticals
- Selecta Biosciences
- Teijin Pharma
- Sobi (Swedish Orphan Biovitrum)
Market Details
| Report Attributes | Details |
| Market value in 2024 | USD 1,050.21 million |
| Market value in 2034 | USD 1,599.24 million |
| CAGR | 4.3 % |
| Base year | 2024 |
| Historical data | 2020 – 2023 |
| Forecast period | 2025 – 2034 |
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Regional Insights
The report provides regionally specific market insights for North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa with regard to the refractory gout market.
North America dominates the refractory gout market, owing to the high prevalence of gout and well-established healthcare infrastructure. The region’s dominance is driven by superior medical facilities, the availability of novel biological medicines, and robust research activity. The region has seen a spike in gout cases, driven by the adoption of unhealthy lifestyles and an aging population, resulting in a greater need for effective therapies.
The refractory gout market in Europe is continuously growing as more people become aware of the ailment and treatment options improve. Countries like Germany, France, and the United Kingdom are in the vanguard of this expansion, thanks to strong healthcare systems and an increased emphasis on biologics and anti-inflammatory therapy. Furthermore, the increasing frequency of gout, particularly among the elderly, has produced a stronger demand for specialist therapies in the region.
Refractory Gout Market Development
August 2023: Novartis announced the diversification of clinical studies for Canakinumab, an IL-1β inhibitor that has shown promising results in controlling different inflammatory disorders, including gout, boosting its market position.
May 2023: Horizon Therapeutics published encouraging findings from its MIRROR trial, confirming Krystexxa’s effectiveness in conjunction with immunomodulation for patients with refractory gout.
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Refractory Gout Market Segmentation
By Treatment Type Outlook (Revenue USD Million, 2020–2034)
- Biologics
- Pegloticase (Krystexxa)
- Canakinumab
- Non-Biologics
- NSAIDs
- Corticosteroids
- Colchicine
- Uricosurics (e.g., probenecid)
By Distribution Channel Outlook (Revenue USD Million, 2020–2034)
- Hospitals and Specialty Clinics
- Retail Pharmacies
- Online Pharmacies
By Regional Outlook (Revenue USD Million, 2020–2034)
- North America
- Europe
- Germany
- France
- UK
- Italy
- Spain
- Netherlands
- Russia
- Rest of Europe
- Asia Pacific
- China
- Japan
- India
- Malaysia
- South Korea
- Indonesia
- Australia
- Vietnam
- Rest of Asia Pacific
- Middle East & Africa
- Saudi Arabia
- UAE
- Israel
- South Africa
- Rest of Middle East & Africa
- Latin America
- Mexico
- Brazil
- Argentina
- Rest of Latin America
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